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Genetic analysis of Lats/Wts family genes using Drosophila and mice models has revealed their role as negative growth regulators and tumor suppressors in animal (Visser and Yang, 2010; Harvey et al., 2013; Yu and Guan, 2013).
A few mice models has been created for lamin A/C knock out or mutations.
Analysis of two different P2X7R KO mice models has revealed differences in skeletal phenotypes, which may be explained by the retention of a functional splice isoform in the Glaxo mouse model.
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Special characteristics for the mice models have been published previously [15, 18, 19].
Enhanced neurogenesis in ALS transgenic mice model has been recently reported (Chi et al., 2007; Lee et al., 2011).
The generation of this AQP4 null mice model has been previously reported [16].
Advancement of genetically engineered mouse models has provided new tools for interrogating these mechanisms.
Human testing of such vaccines, although protective in mouse models, has produced mixed results.
The intestine from cystic fibrosis mouse models has been described as presenting mucus accumulation and changes in morphology that include enlargement of the villi32,36,39,40.
Readers of this unique reference will see that the study of mouse models has already demonstrated real translational prowess in vision research.
Emerging evidence from mouse models has identified the importance of BACE1 in myelination and cognitive performance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com