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Thus, βENaC-Tg mice may represent a useful model for further studies into the biology and function of miR-221 in CF lung disease.
Thus, Atxn2 knockout mice may represent an additional rare example of dissociated hippocampal and amygdalar synaptic plasticity [25] [27].
Attenuation of IGF-1 signaling, as observed in the XpdTTD mice, may represent a general, hormonal response to increased stress including genotoxic stress [36] [36].
Consequently, gnotobiotic IL-10−/− mice may represent a novel means to uncover pathways and regulatory host response mechanisms intrinsically associated with C. jejuni pathogenesis.
Thus increased miR-1 in skeletal muscle of exercised mice may represent an adaptive response to oxidative stress imposed by acute exercise.
Given the neurotrophic roles attributed to sAPP, the enhanced stability of sAPP in the β-amyloid depositing Tg2576 mice may represent a neuroprotective response.
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A cat playing with a mouse may represent the Devil snaring a human soul.
Even though this resulted in a comparable ratio of β/ α-MHC between the WT and OPN−/−-mice, the increase in metabolic turnover in OPN−/−-mice may represent an additional burden under ischemic stress.
It is now apparent, however, that the XCI strategy found in the mouse may represent just one of many modes of regulating X-chromosome gene dosage in mammals (Fig. 1).
This type of astrocytic response is observed in all our model systems of transmissible prion disease, but is absent from the nontransmissible forms of PrP (i.e., amyloid plaques in absence of clinical disease), suggesting that this single mouse may represent a transmission of infection rather than a consequence of seeding of inoculum (25, 28 ).
Thus, the GAP-43: luciferase-GFP mouse may represent not only a suitable in vivo model to assess the innate regenerative process of the mature CNS but also a qualitative marker of the efficacy of therapeutic agents to promote this repair.
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