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Thus, increased myostatin expression in PPARβ-deficient mice may at least partly explain their poor muscle strength.
Thus, the cardiac phenotype observed in αII-Spectrin-deficient mice may, at least in part, be related to the failure to complex with Mena and VASP at Z- and intercalated discs.
Cultured neural precursor cells from the SVZ of Hq mice displayed a slower proliferation rate and were more resistant to IR. IR preferentially kills proliferating cells, and the slower proliferation rate in the SVZ of Hq mice may, at least partly, explain the protective effect of the Hq mutation.
In the NOD mice, no augmentation of saliva flow rates has been observed after infusion of neuropeptides combined with muscarinic cholinergic agonist [ 8], indicating that the hyposalivation observed in NOD mice may, at least in part, be due to a general loss of neurotransmitter responsiveness in salivary glands.
Therefore, we suggest that the increase in CB1R-positive terminals observed in the Rac1N mice may at least in part explain the negative effects observed on different forms of memory in these mutants.
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Thus, the reduction of ROS at sites of inflammation and neovascularization in IQGAP1−/− mice may be at least due to a decrease in the number of infiltrated inflammatory cells and angiogenic ECs as well as their ROS producing capacity.
From the initial insight that the thermogenic markers of canonical BAT were not different between the two genotypes, we rationalized that the increased thermogenic capacity observed in the Bmp8b TG mice may depend, at least in part, on the BAT-like phenotype observed in their ScW.
The results indicate that the same mechanisms that slow the aging process in mice may be at work in people, says Fontana, whose team reported its findings 17 January in the Journal of the American College of Cardiologists.
Hence, the decreased bone formation in vivo in Akt1-/ mice may be at least in part due to the deficit of anabolic IGF-I signaling.
Indeed, maternal metabolism is important because the different impaired glucose tolerance and blood parameters observed in F0-BPA10 F0-BPA100A100 mayexplainxplatn, at least in part, the different metabolic abnormalities displayed subsequently in their offspring (F1-BPA10 F1-BPA100A100 mice, respectively).
In addition to this direct effect, acanthosis of infundibula in K5cre-CMVcaNrf2 maye may result at least in part from upregulation of Sprr2d and subsequent disruption of the follicular barrier.
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