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Microglia in TERC KO mice maintained a homogenous distribution and normal expression of CD45 and CD68 and the aging marker, ferritin, but were morphologically distinct from microglia in both adult and old wild-type mice.
Raised alongside unaltered mice and fed the same diet rich in omega-6's, the transgenic mice maintained a one-to-one omega-6 to omega-3 fatty acid ratio, compared to a 20-to-1 ratio in the normal mice.
Moreover, NSC from adult Mecp2tm1.1Bird+/− female mice maintained a stable frequency of expressing cells from the first to the 10th sphere.
In contrast, mutant mice maintained a low hematocrit for at least two more days and 25% of them died at day 4 or 5.
The majority of Treg cells present in healthy mice maintained a stable suppressor phenotype, expressed high level of Foxp3 and an exclusive set of TCRs not used by naive CD4+ T cells.
Serum 17β-estradiol progressively decreased in the VDR KO mice beginning at 8 months of age whereas WT mice maintained a relatively constant 17β-estradiol serum level through 16 months of age.
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Further, CNR1 knockout mice maintain a favorable lipid profile during high-fat diet [36], [37].
Our results showed that older Ghsr-/ mice maintain a youthfully lean phenotype, with a decreased percentage of body fat and increased lean mass; whereas Ghrl-/ mice do not.
We show that Rev-Erbα−/−Per1Brdm1 double mutant mice maintain a functional circadian clock although they display a shorter period with higher variance between individuals.
In contrast to the human PWS phenotype, the Snord116del mice maintain a stable body weight as adults, indicating proper feeding regulation under normal conditions.
Both our work and previous studies have demonstrated that HeJ mice maintain a higher renal bacterial burden than HeN mice (Shahin et al., 1987).
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