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However, granulomas from Mtb infected humans and mice maintain significant CD4+ T cell activation and IFN-γ production [8] [9].
Mice maintain significant stores of vitamin A in their livers in the form of retinol, so Rbp4−/− mice, which cannot mobilize these stores and depend on dietary retinol, were used to assess the effects of vitamin A depletion during ENS development.
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We found that hepatic glycogen in WT mice was virtually absent after 24 hours of fasting whereas RasGrf1 −/− mice maintained significant glycogen levels.
D2 female mice maintained on HFD showed significant increases in branch elongation and number of terminal end buds compared with those maintained on LFD (p < 0.01; Figure 4A,B).
"Everyone is maintaining significant ownership," he said.
Consistent with the difference in body weights between the TG and WT males, DEXA analysis of 22-week-old TG male mice maintained on regular chow showed significant reductions in total tissue mass, total tissue area, fat mass, and lean mass (Table 4).
We analyzed quantitative Bmpr2 gene expression in whole lungs of ovariectomized female mice compared to male mice maintained otherwise identically, and again found a statistically significant difference in terms of Bmpr2 gene expression.
The double transgenic CaM/Tet-DTA mice, maintained on a (B6/CBA) background, represent a model of hippocampal neurodegeneration with significant loss of CA1 pyramidal neurons; have also previously been characterized (Yamasaki et al., 2007).
However, a significant difference in colonization levels developed by day three post-infection, such that D2 mice maintained colonization while B6 mice began to resolve the infection (Fig. 1b).
Through 4 weeks of HF feeding, KO mice, unlike WT mice, maintained normal insulin sensitivity.
While the saline-treated control mice maintained normoglycemia during the entire study period, the STZ-treated mice had a progressive increase in the blood glucose level each day thereafter (230±14, 295±14, 329±16, and 334±15 mg/dl, respectively), resulting in a significant difference from that of the control mice on days 2, 4, 6 and 8 (p = 0.002, 2.98×10−5, 4.49×10−6 and 1.25×10−6 respectively).
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