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CCR9−/− mice lost significantly more weight than WT animals.
After infection with 2x10 Focus Forming Unit (FFU) PR8M virus, Irf7−/− mice lost significantly more body weight and exhibited increased mortality compared to wild type controls (Fig. 5a, b).
Notably, IL-25−/− mice lost significantly less body weight during the first two cycles of DSS exposure and recovered faster after the switch back to water compared to DSS-treated WT mice.
When compared with the age- and sex-matched WT mice, IL-13−/− mice lost significantly more body weight and developed exacerbated disease activity during the course of acute DSS exposure, contrary to that observed in IL-25−/− mice.
After BLM intubation, both wild-type and transgenic mice lost weight at similar rates for the first five days, from which transgenic mice lost significantly more weight as compared to wild-type (Fig. 2a).
Major weight loss was observed in several individual mice of other strains as well, but for strains analyzed as a group, only the QD mice lost significantly more body weight than the control group (data not shown).
Similar(53)
Surprisingly, NK1.1 depleted mice did not appear to have much more severe systemic morbidity as their weight loss did not exceed 10% of initial weight, in contrast with isotype treated mice, which lost significantly more weight during the peak of infection (Figure 5F).
RSV-infected mice treated with anti-CCL3 losignificantlytly more weight than control mice on days 6 and 7 p.i. (p<0.001, Figure 5a).
In addition, mice infected with the sigS mutant lost significantly less weight than mice infected with SH1000.
Mice treated with anti-TNF lost significantly less weight than control mice at the peak of disease (p<0.01, Figure 6a).
The first part of human chromosome 5q maps to the telomeric half of mouse chromosome 13, which is not lost significantly more often in the mouse Brca1 Δ/Δ ;p53 Δ/Δ tumors compared to the p53 Δ/Δ tumors, with the exception of the telomeric region.
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