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They were studying the effects of alcohol withdrawal in mice, looking for new ways to help people overcome addiction.
Joseph Takahashi and colleagues at Northwestern University studied mutated mice, looking for animals that showed a disturbance in their daily patterns of running in their exercise wheels.
In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythm.
Mice adopting a circular swimming strategy at a constant distance from the wall will have a crossing index close to zero, mice looking for the platform at the wrong place will have a negative index, while mice having a good spatial strategy will have a positive index.
Remove the following types of clutter to make your home less inviting to mice looking for a place to build a nest: Boxes of old cookware.
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The longer the mice look for the platform at its former site, the better they are thought to have memorized the location.
(4) If the transcription factor-binding sites are not conserved between human and mouse, look for regions with low "Hits" but with increased transcription factor-binding site frequency in human, followed by examining the tissue distribution.
AROUND this time of year, mice start looking for a place to spend the winter.
"This is the time of year that rats and mice start looking for warmth, food and shelter," said Arthur Katz, president of Knockout Pest Control in Uniondale, N.Y.
The team screened thousands of known genes in whole mice brains, looking for those switched on or off by the FOXP2 protein.
"It's a little bit of cat and mouse and looking for your opportunities to make plays".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com