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In CCR4-/ mice, lethality, tissue injury and systemic inflammation were markedly decreased.
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Mouse lethality assay.
In contrast, the injection of recombinant HMGB1 increased septic mouse lethality [22].
This laboratory has also used the mouse lethality test extensively.
The neutralizing capacity of the antibodies was evaluated in the in vivo mouse lethality test.
The neutralizing capacity of the antibody was evaluated in the in vivo mouse lethality test.
Data from mouse lethality studies were analyzed with Fischer's exact test.
Palytoxin comes in second with an IP mouse lethality of 300 ng/kg [30].
In marked contrast to TRF2 deletion in the liver, TRF2 ∆/∆ -K5-Cre mice show lethality in utero reaching 100% lethality perinataly.
Mouse tissue was provided to Celera by the Jackson Laboratory of Bar Harbor, Me., a leading mouse colony.
Having tissue-specific and temporal control of gene expression in any mouse tissue at any developmental stage could allow for the dissection of biological gene functions that were previously masked by a phenotype such as lethality.
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