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In mice lacking of TAp63, the Corti organ displays abnormalities respect the number of inner and outer hair cells (IHC, OHC).
Finally, using genetic mice lacking of prion protein (Prnp0/0) we characterized the underlying molecular cascades and found that STI-1 promotes the homing of BMDCs via its interaction with cellular prion protein (PrPC).
LPA is increased in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and mice lacking of its receptors, LPA1, are protected from injury [ 20].
Recently, mice lacking of mir-155 are resistant to collagen-induced arthritis (CIA) [ 8], whilst administration of mir-146a complexed with aterocollagen into joint attenuates pathological condition of CIA [ 9].
Mice lacking of Ang-1 and Tie-2 showed defective remodelling and maturation of the vasculature, whereas the transgenic mice overexpressing Ang-1 displayed increased vascularization suggesting a role in the formation of blood vessels during development [ 87].
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The most compelling evidence for a role of α-syntrophin in muscle development comes from investigation of muscle regeneration in a knockout mouse lacking of the α-syntrophin [20].
However, Ziegler and colleagues found normal proportions of Treg in the thymus of mice lacking expression of the IL-15Rα chain, which is only involved in signalling via the receptor for IL-15 (Soper et al., 2007).
Foetuses of mice lacking one of the essential zinc importers, slc39a4 (zip4), become critically zinc deficient and show severely underdeveloped and deformed craniofacial and limb features [ 48].
We report here the craniofacial features of mice lacking function of the Shh co-receptors Gas1, (Cdon) and Boc, focusing on the effects of combined Gas1 and Boc loss-of-function.
While sharing several structural and functional similarities, specific properties for TIAR and TIA-1 are suggested by the partially diverging phenotypes of mutant mice lacking either of these two proteins.
Quantitation of DCs in mice lacking either of the enzymes needed for 7α,25-OHC synthesis, CH25H or CYP7B1, showed a comparable selective loss of CD4+ DCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com