Sentence examples for mice lacking hepatic from inspiring English sources
In addition, mice lacking hepatic ARNT show reduced hepatotoxicity following treatment with TCDD [ 21].
In the present study, metformin was found to inhibit glucose production normally in transgenic mice lacking hepatic AMPK catalytic subunits or LKB1.
Histopathological analysis showed that fibrotic tissue remodeling was significantly enhanced in rac1 knockout animals and further increased with age in mice lacking hepatic rac1 gene.
A novel cancer phenotype in which mice lacking hepatic androgen receptor (AR) developed more undifferentiated tumors and larger tumor size at the metastatic stage, which AR could orchestrate intrahepatic signaling hierarchies and cellular behaviors, consequently affect HCC progression [ 22].
We examined three different mouse models of Rictor loss: mice heterozygous for Rictor, mice lacking hepatic Rictor, and mice in which Rictor was inducibly deleted throughout the body in adult animals.
Both male and female mice lacking hepatic Rictor showed decreased glucose tolerance, while both male and female mice heterozygous for Rictor have normal glucose tolerance, suggesting the male-specific decrease in lifespan does not result from decreased glucose tolerance or insulin resistance.
Like mice lacking primary UPR components, hepatic Lrh-1-null mice cannot resolve ER stress, despite a functional UPR.
In the liver, 5-HT appears to mainly promote constriction of hepatic sinusoids, since mice lacking peripheral serotonin (Tph−/−) display enhanced sinusoidal perfusion under both normal and diseased states [10].
The expression of Nocturnin is robustly rhythmic in liver at both the mRNA and protein levels, and mice lacking Nocturnin are resistant to diet-induced obesity and hepatic steatosis.
The PASK gene, whereby expression was up regulated in the LBW animals, has been shown to be a metabolic sensor based on mice knock-out studies; mice lacking PASK are resistant to high-fat induced obesity, hepatic steatosis and are resistant to insulin [ 35].
Knockout mice lacking hepatocyte IL-6Rs exhibit skeletal muscle insulin resistance but hepatic glucose production is unaltered.
