Retardation was significantly greater in knockout mice lacking both reductases.
Knockout mice lacking both TRIC-A and TRIC-B channels suffer from embryonic heart failure.
In mice lacking both ankyrin-G and ankyrin-R, Na+ channels fail to cluster at nodes.
Ni, H. et al. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen.
van den Broek, M. F., Muller, U., Huang, S., Aguet, M. & Zinkernagel, R. M. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
Oliverio, M. I. et al. Reduced growth, abnormal kidney structure, and type 2 (angiotensinensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.
Since OPN shares receptors with vitronectin (VN), we tested for compensation by creating mice lacking both OPN and VN.
Hypotension and renal histological abnormalities in triple knockouts were comparable to those in mice lacking both AT(1) subtypes.
Paralleling the change in tau phosphorylation levels, we found that GSK-3beta activity increased in Reln-deficient mice and further increased in mice lacking both Reln and ApoE.
The team found the gene for a key enzyme, desmosterol reductase, which converts desmosterol to cholesterol, and created mice lacking both copies of the gene.
A delay in recovery of the rod a-wave is also seen in mice lacking both GCAP1 and GCAP2.
