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Doré's team had discovered that mice lacking an enzyme called heme oxygenase recovered poorly from stroke.
In that work, researchers reported that mice lacking an obscure protein, Mahogunin, suffered a form of neurodegeneration much like prion disease.
The team, led by molecular biologist Brian Kennedy of the Merck Frosst Center for Therapeutic Research in Pointe Claire-Dorval, Quebec, and biochemist Michel Tremblay of McGill University in Montreal, created a line of mice lacking an enzyme called protein tyrosine phosphatase-1B (PTP-1B).
Several animal models have been generated to study the pathogenesis of CDG IIc: FX locus null mice, lacking an enzyme in the de novo GDP-fucose synthesis pathway [5], Gfr (homologous to FUCT1) null flies [6] and Fuct1 null mice [7].
Recent genetic studies have shown that mice lacking an autophagy-related gene (Atg5 or Atg7) cannot survive longer than 12 h after birth because of nutrient shortage.
CAIA has been induced in mice lacking an adaptive immune system, showing a direct role of anti-CII in arthritis development [ 7].
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For instance, myoblasts from mice lacking A-type lamins that exhibit signs of muscular dystrophy plate with high viability and proliferate normally, but ultimately have impaired differentiation [39].
In obese mice lacking A-FABP, dyslipidemia and peripheral insulin resistance are improved and β-cell function is preserved (11).
This was not apparent in mice lacking a functional NOS-2 gene.
To investigate further, the team studied mice lacking a functional PER3 gene.
In mice lacking a receptor for this protein, maturation of neuronal connections was delayed.
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