Exact(57)
This was not apparent in mice lacking a functional NOS-2 gene.
To investigate further, the team studied mice lacking a functional PER3 gene.
In mice lacking a receptor for this protein, maturation of neuronal connections was delayed.
However, mice lacking a functional eNOS enzyme, as present in eNOS-/ and double KO mice, perfusion in jejunal tissue did not decrease during LPS infusion.
The team then turned to mutant mice lacking a gene important for guiding axons, the tendrils extending from neurons.
This study was designed to investigate whether neuronal nitric oxide mediates the actions of agmatine in morphine dependence by using mice lacking a functional form of this enzyme.
In a separate experiment, bacterially induced preterm delivery was compared between mice lacking a functional IL-1 receptor and wild-type control litter mates.
We demonstrated that killing curves from mice lacking a functional fas receptor and wild-type controls were not different over a wide range of therapeutically relevant concentrations.
Similar(3)
For instance, myoblasts from mice lacking A-type lamins that exhibit signs of muscular dystrophy plate with high viability and proliferate normally, but ultimately have impaired differentiation [39].
In obese mice lacking A-FABP, dyslipidemia and peripheral insulin resistance are improved and β-cell function is preserved (11).
Moreover, mice lacking A-type lamins develop to term without overt abnormalities (Sullivan et al., 1999), indicating that lamin A deficiency itself does not negatively affect embryonic development and differentiation during fetal development.
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