Moreover, Mpi knock-out mice die in utero (DeRossi et al., 2006), whereas heterozygous humans and mice lack detectable abnormalities.
This is rather surprising, as nonimmunized DBA-lpr/lpr had significantly higher levels of anticollagen antibodies than wild-type mice, which almost lacked detectable antibody levels.
As expected, these ALDH2-null mice lacked any detectable ALDH2 enzyme activity, accumulated a high level of acetaldehyde when exposed to ethanol, and were significantly more sensitive to alcohol and acetaldehyde toxicity and damage.
In contrast to serum from SHe-KLH-vaccinated mice, sera from HRSV-infected or KLH-vaccinated mice and all human sera lacked detectable SHe-specific IgG antibodies (Fig 8A and C).
Indeed, Dnmt2−/−; Nsun2−/− double-knockout mice, which lack detectable cytosine-5 tRNA methylation, showed lower steady-state levels for various tRNAs and a reduced rate of global protein translation (Tuorto et al, 2012).
We have also included new RT-PCR data demonstrating that SVZ cells, GEPCOT cells, and pre-GEPCOT cells from Nestin-Cre; Bmi-1 fl/fl mice generally lack detectable Bmi-1 mRNA, in contrast to littermate controls (see new Figure 6-figure supplement 1G).
Only cells from those tumors that were highly cellular (enhanced cell cell interactions) and lacked detectable desmoplastic hyperplasia (minimal stromal involvement) could be grown and serially transplanted into nude mice.
82 The synthetic peptide-in-oil formulation (MOG34 56/IFA) lacked detectable innate stimulatory activity and therefore did not elicit EAE in Biozzi ABH and C57BL6 mice.
We identified 5 sets of syntenic and functionally homologous zebrafish and mouse ECRs: these enhancers were able to drive overlapping spatiotemporal patterns of expression in a zebrafish reporter construct, but lacked detectable sequence conservation.
Interestingly, glomerula lacked detectable signals indicative of PrPSc.
