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Here, we show that the dorsal skin fold chamber preparation of mice is well suited for the testing of skin substitutes in vivo.
In contrast, the ability of many human ALL cell populations to expand when transplanted into highly immunodeficient mice is well documented.
The method and PTU-dosing regimen for reliably reproducing the hypothyroid state in mice is well established in the literature [ 16- 20].
Sexual dimorphism in picornavirus infections, including coxsackievirus B3 (CVB3), in mice is well documented with males showing more severe disease than females [ 28- 30].
Of note, comparing genetic NR2F6 deletion with blocking interaction of PD-1 with its ligand PD-L1 provides evidence that the observed superior anti-tumor immunity in Nr2f6−/− mice is well comparable to the benefit of PD-L1 blocking therapy in wild-type mice (employing the established protocol with neutralizing Ab10F.9G2; Gros et al., 2014).
The influence of genetic background on heart abnormalities in mutant mice is well established and our detection of strain-dependent variation in the prevalence of Tc1 cardiac malformations is reminiscent of the finding that the prevalence and subtypes of CHD associated with DS vary in different human populations.
Similar(54)
The ability of complete Freund's adjuvant (CFA), a potent activator of APC, to prevent type 1 diabetes in NOD mice is well-established, and although protection has been attributed to a variety of different cells, including suppressor T cells, NK cells and suppressor macrophages [23] [25], the precise mechanism is unknown.
Even though these mice were well fed, their own young were also born unusually small and with a higher risk of diabetes.
But they're "part of a whole series showing that bone helps regulate other tissues, and the findings in mice are well done and compelling".
But in sharing their genome and serving diligently as guinea pigs in genetic tests, mice are well into repayment of their long-term debt.
Behavioral performance was impaired during the learning phase but not after the mice were well trained.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com