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Interestingly, the reduction in fibre volley we report in CD and KD fed epileptic mice is more profound than in control CD and KD fed mice.
This indicates that although the effects of GF rearing on the latter behaviour are permanently established in the pre-weaning period, the development of social avoidance in GF mice is more amenable to microbial-based interventions in later life.
These findings suggest that object memory consolidation in young female mice is more sensitive to the modulatory effects of progesterone than spatial memory consolidation, at least using the tasks, doses, and delays tested.
Diabetes causes a shift in oral bacterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mice is more pathogenic.
Surprisingly, mutant JAK2V617F allele burden in the blood of splenectomized mice is more than double the burden in SH (Fig 2C).
It is of interest that tumor growth of Ras-transformed MEFs in nude mice is more highly suppressed by Stat1S727A than Stat1 WT (Fig. 5).
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Treated mice were more energetic and had better memory.
Conversely, OCTN1 knockout mice are more prone to oxidative stress15.
Figure 10: LSD1 Tg mice are more sensitive to cold exposure.
Tg mice were also more insulin sensitive, as determined by insulin-sensitive test (Fig. 9g), showing that Tg mice are more resistant to HFD-induced type-2 diabetes.
Both Cd69 /– and Itgae /– mice were more susceptible to melanoma formation than were wild-type mice (Fig. 2g, h).
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