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It should be noted that complete lack of leptin activity is a very rare cause of severe obesity in humans, while HFD-fed mice is generally accepted as a good model for the common clinical obesity due to the combined effect of high caloric density diet and multigenic predisposition [20], [21].

The capacity of reproduction of germfree mice is generally lower.

Pre-anesthetic fasting in mice is generally deemed unnecessary because the animals cannot vomit.

The incidence of arthritis in CIA-susceptible strains of mice is generally very high, reaching 50 100% in most strains [ 44].

Breeding of Tp53 Δ11/Δ11 null mice is generally avoided because early onset of lymphoma occurs shortly after puberty and adults infrequently survive long enough to successfully raise litters (Donehower et al., 1992).

A number of cytokines are released to modulate the microenvironment of the injured tissue, and acute cardiac inflammation in adult mice is generally believed to exert a negative effect on heart regeneration by promoting fibrotic scar formation.

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Laboratory mice are generally euthanized using CO2.

No strains of mice were generally sensitive or resistant to intoxication across tasks.

COX-1 had long been considered the 'housekeeping' cyclooxygenase, and therefore it was surprising that these null mice were generally healthy, displaying no immediately obvious pathology.

First, they found that the cancerous liver cells in their mice were generally accompanied by cells that had the symptoms of old age (they had, for example, stopped replicating).

All 128 Hdac6 tg mice are generally healthy, with the exception of only one mouse showing abnormal neck growth.

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