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The onset and progression of SLE in female lpr mice is extremely consistent [28].

The telomere length of laboratory inbred mice is extremely long (∼50 150 kb) [34], [35], whereas the length of zebrafish telomeres (∼4 20 kb) is much closer to that of human telomeres (∼8 10 kb) [23], [24], [36].

The origin of the mice is extremely important because laboratory mice are available as both outbred stocks and inbred strains from various vendors.

As the survival rate of PPARγ-deficient mice is extremely low (Duan et al., 2007), the role of PPARγ signalling in the heart is only poorly understood and highly controversial.

The 'normal' adult microbiota of humans or mice is extremely diverse and consists of hundreds (or thousands) of bacterial species reaching densities of up to 10 bacteria per gram content in the large intestine.

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STING deficient cells fail to produce type I interferons post cytoplasmic DNA stimulation (Ishikawa and Barber, 2008) and STING knockout mice are extremely susceptible to herpes simplex virus 1 infection (Ishikawa et al., 2009).

Regular chow fed homozygous Leptin145E/145E mice were extremely obese and infertile.

HLA-DR3 transgenic mice are extremely sensitive to TSS without the use of any sensitizing agents and faithfully recapitulate human TSS [19].

Because forelimb skeletal elements that formed in dcko mice were extremely small and misshapen, we examined endochondral growth and ossification on less severely affected hindlimb.

However, the authors reported that in other published experiments with P. berghei sporozoites the ID50 of sporozoites inoculated intravenously to CD-1 mice was extremely high (1,700 to 11,500) indicating that the sporozoite infectivity was extremely poor [9], [10].

However, many standard phenotyping procedures for laboratory mice are extremely challenging to perform in wild-derived inbred strains [18], [22], and are likely to prove to be similarly difficult to carry out in wild-caught mice.

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