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The effect of rendering Sp1 inactive in mice is dramatic.
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The defect in EM phenotype cells in ICOS−/− mice was dramatic and suggested that there might either be a defect in development or reduced homeostatic proliferation of these cells.
Cage effects in conventionally housed mice are dramatic.
Whereas mitochondria with lowered ΔΨm are abundant in all three preparations and probably reflect oxygen depletion due to a time lag in imaging, differences between Plp1tg mice with wild-type and jp mice are dramatic.
This may also explain why high TSLP levels in fetal or neonatal Notch mutant mice cause a B-LPD [13], while the effect on B cells in adult mice is less dramatic.
Another mechanism suggested to contribute to decreased fat stores of HSL null mice is the dramatic reduction in reesterification of fatty acids in WAT, which in turn is due to the coordinated alteration in the expression of enzymes involved in lipogenesis [27].
The most remarkable phenotype of mutant mice is the dramatic alopecia.
This is in contrast to mouse kinome in which there is dramatic expansion of Microtubule affinity-regulating kinase (MARK) gene, loss of a few protein kinase genes as compared to human kinome and lineage specific protein kinases derived from retrotransposition [ 24].
Therefore, the observed increase in the median lifespan is dramatic, taking into account that it was achieved in male mice.
The change is dramatic.
The turnabout is dramatic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com