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The development and maintenance of breeding colonies of mice is an integral part of biomedical research for nearly a century.
Cold transport of epididymides from genetically modified mice is an efficient alternative to the shipment of live animals between research facilities.
Acetaminophen-induced liver injury, especially in mice, is an attractive and widely used model for this purpose because it is both clinically relevant and experimentally convenient.
An essential complement to molecular-genetic approaches for analyzing the function of the oculomotor circuitry in mice is an understanding of sensory and motor signal processing in the circuit.
The development of experimental procedures for the recording of neuronal activity in awake and behaving mice is an important and necessary step towards neurophysiological investigation of normal and pathological mouse brain function.
Also, because MICE is an iterative imputation method, its convergence needs to be evaluated.
Taken together, these results demonstrate that Krm2, at least in mice, is an endogenous inhibitor of bone formation.
Adoptive transfer of DC transduced to express IL-4 into both normoglycemic and prediabetic NOD mice is an effective treatment for T1D.
A third possible explanation for the lymphocyte developmental defects observed in Lmna-/ mice is an indirect effect of laminopathies at distal sites.
The generation of human CEACAM1 transgenic mice is an important model to demonstrate equivalence in function of the murine and human gene orthologs.
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Altogether, these findings show that metabolic imbalance in muscle fibers of SOD1G86R mice is an early event.
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