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Importantly, no adverse effects were seen in muscle of wild-type mice injected systemically with scAAV.hSGCB.
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Separately, adult mice were injected systemically (i.p).
Current xenograft models of breast carcinoma involve murine or human breast cancer cell lines implanted into the mammary fat pad of mice or injected systemically by intravenous or intracardiac routes.
SVZ lysates from the mice that were injected systemically over a three day period showed that the proliferative marker Ki67 was upregulated 30% by each of the FAK inhibitors.
Only tumors demonstrated GFP expression in both control (data not shown) and experimental mice (Fig. 4a) injected systemically with rQ-M38G.
By injecting radioactive α-bungarotoxin into pleural cavities of mice that had been injected systemically with myasthenia gravis antibodies, he was able to label the diaphragm AChRs and show that they did indeed turnover faster (see also Stanley and Drachman 1978), but, unexpectedly, their synthesis rate also increased.
Fluorescently labelled CD4+ and CD8+ T lymphocytes taken from the spleens of naive mice or mice previously immunized with RENCA-IL-2 were injected systemically into tumour-bearer mice.
Methods: Ad vectors, AdMKTK or AdCMVTK, encoding HSV-tk under the control of the MK or cytomegalovirus promoters, respectively, were injected systemically into mice, then hepatotoxicity and survival was monitored after GCV administration.
These Th2 biasing analogs induce similar IL-4 production but much weaker and more transient IFNγ production when injected systemically into mice when compared to KRN7000.
To determine apoptosis in vivo following treatments, mice bearing bilateral PC3 xenografts were injected systemically with vehicle or 4 mg/kg doxorubicin, followed by intratumoral injection of vehicle (left tumor) or Apo2L/TRAIL (right tumor).
Our data demonstrate that cytokine-expressing bacteria modulate macrophage activation independently of their entry into cells and may explain the rapid action of these bacterial strains when injected systemically into susceptible mice.
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