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As expected, chronic CCl4 administration to C/EBPβ+/+ (wt) mice, induced marked activation of HSC, as indicated by the positive immunofluorescence for α-SMA within the scar tissue [5] [6] (Figure 4A), and proliferation of HSC, as indicated by the presence of proliferating cell nuclear antigen (PCNA; DNA polymerase δ auxiliary protein), an S-phase marker [28] (Figure 4B).
In contrast, diazepam treatment in 129P3 mice induced marked sedation.
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As shown in Fig. 1, compared with saline treated mice, BLM induced marked hypodermal thickness (Fig. 3A and 3B), increase of ECM deposition and collagen contents (Fig. 3C and 3D), enhancement of the transcription levels of Col1a2 and Col3a1.
In ADAtg mice, PAN neither increased proteinuria nor induced marked sodium retention.
Expression of mTOR(L2209V) induced marked transformation of mouse 3T3 cells, whereas that of the wild‐type protein did not (Fig. 1c).
injection of this tumour induced marked thrombocytopenia in normal mice.
A high-concentration glucose challenge (16.7 mM) induced marked insulin secretion in both strains of mice, but insulin secretion in db/db mice remained less than that in m/m mice.
Our hypothesis is also supported by the observation that anti-HA antibodies induced marked recovery in 7-month-old hemizygous mice However, recovery was observed on the second trial day and not the third trial day.
This approach demonstrated that CR induced marked changes in the metabolite profile of mice which reinforced our lipidomic data.
Fumagillin treatment induced marked adipocyte hypotrophy associated with enhanced density compared to mice fed a high fat diet ad libitum, but less marked compared to pair fed control mice.
Activation of mouse T cells using plate-coated anti-CD3 and -CD28 antibodies induced marked down-regulation of hCCR5 from the cell surface (Figure 1A and Discussion).
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