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Intranasal administration of these recombinant lactococci in mice induced an HPV-16 E7-specific immune response.
When CD40 was engaged for 20 hrs, both populations from NOD, BALB/c, and NOR mice induced an increase in CD40 expression demonstrating a positive feedback loop.
Taken together, this indicated that HSP70 immunization of IL-10−/− mice induced an HSP70-specific B and T cell response that, in the absence of IL-10, failed to suppress PGIA development and PG-specific pathogenic IgG2a production.
In contrast, in the absence of IL10, CpG-ODN administration by IP route in adult mice induced an over-expression of CXCL1 (400-fold greater), CXL10 (356-fold greater), CCL2 (357-fold greater) and CCL7 (205-fold greater) (Fig. 6B).
This effect was not tumor mediated because injection of TBHsp70 in tumor-free mice induced an increase of Tregs in the draining lymph nodes as well as inhibition of proliferation of lymph node T cells and an increase in IL-10 production.
These results suggest that a deficiency of SASPase in hairless background mice induced an abnormality in the SC.
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First, we showed that dorsal hippocampal but not medial prefrontal cortex lesions in C57Bl6 mice induced a time-dependent impairment of spatial recognition.
More importantly, transfer of IL-35Ig−transfected, IGRP-pulsed DCs into prediabetic NOD mice induced a delayed and less severe form of diabetes, an effect accompanied by the increase of CD4+CD39+ suppressive T cells in pancreatic lymph nodes.
Classical DCs derived from Balb/C mice induced a strong proliferation of T cells in a mixed lymphocyte reaction (MLR).
It has been previously shown that TRα gene invalidation in mice induced a significant decrease in body temperature [21].
Fat feeding in 129S6 mice induced a statistically significant general raise of plasma TC, HDL-C, LDL-C and TG.
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