However, over the next 4 months the weight of the mutant 569 mice increased, so that at 6 months the difference with the wild-type was no longer statistically significant, and later mutant 569 mice became significantly heavier.
In the present study, HFD + H-HBCD mice had increased mRNA levels of F4/80, Cd11c, and Tnfa (although not statistically significant) and increased macrophage accumulation in adipose tissue compared with HFD + vehicle mice.
Injured mice exhibited increased levels of serum CTX-I at all time points compared to uninjured mice for all treatment groups, although this difference was statistically significant primarily at 14 days post-injury.
CreLysM Casp8fl/fl mice exhibited increased numbers of Ly6Chigh and Ly6Clow splenic CD11b+F4/8 0+cells, whereas the CD11b+F4/8 0−Ly6G+neutrophils and CD11b−F4/8 0+red pulp macrophage populations were not statistically altered compared with control mice (Fig. 2a).
In comparison with control mice, the values of serum ALT, AST, GGT, ALP, CK, creatinine, glucose, and cholesterol were statistically increased in mice treated with tea leaves extract plus diazinon (group 3), olive leaves extract plus diazinon (group 4), and tea and olive leaves extracts plus diazinon (group 5).
The value of serum triglycerides was statistically increased in mice treated with tea leaves extract plus diazinon (group 3), olive leaves extract plus diazinon (group 4), while the value of serum triglycerides was significantly unchanged in mice supplemented with tea and olive leaves extracts plus diazinon (group 5).
Compared with WT mice, the crypt epithelium in Fus1−/− mice displayed statistically significant increase in apoptosis at 4 and 8 h post IR.
In bone marrow samples from 5T multiple myeloma diseased mice, a statistically significant increase of the microvessel density was observed when compared to bone marrow samples from age-matched controls.
Both the Het and KO mice presented statistically significant increases in the number of osteoclasts, while there was no significant difference in either the osteoclast area or the Oc.S/BS measurements.
Relative to air-breathing mice, a statistically significant increase in sensitisation was observed with both a local tumour control and with an in vivo/in vitro excision assay (P < or = 0.007).
