Sentence examples for mice inactivation of from inspiring English sources

In male mice, inactivation of MTHFR results in hyperhomocysteinemia and infertility with abnormal testicular histology characterized by absence of germinal cells and spermatogenesis arrest [28].

In 129 strain mice, inactivation of Dnd1, as in the 129-Ter mouse strain, causes loss of germ cells and in addition, development of testicular germ cell tumors [3].

In mice, inactivation of Mbnl1 is known to alter Clc-1 splicing to result in myotonia.

In mice, inactivation of the specific mutant MYH6 transcript suppresses hypertrophic cardiomyopathy [ 75].

In mice, inactivation of the paternally inherited X chromosome is initiated at the four-cell stage (Fig.  1b).

In wild-type mice, inactivation of TRPV1 expressing sensory terminals with the vanilloid, resiniferatoxin, similarly augmented Oxa-induced ear edema.

Moreover, mice with diminished expression of Beclin 1 and mice with inactivation of Atg7 in microglia/macrophages are susceptible to cerebral and ocular toxoplasmosis despite upregulation of IFN-γ, TNF-α and NOS2 as well as the induction of T cell-mediated immunity.

To further investigate this we generated neural stem cells (NSCs) from embryonic day (E) 14 wild-type and A10 cKO mice with inactivation of the Adam10 gene in neuroectodermal progenitor cells (NestinA10 KO mice) (Jorissen et al., 2010).

In conditional PTEN knock-out mice, upon inactivation of PTEN, there is a transient increase in hematopoietic CICs and a myeloproliferative disease develops and the mice subsequently develop leukemia after 4-6 weeks [ 204].

In mice with inactivation of tumor suppressor genes BRCA1 and p53, an amplicon containing only the YAP gene was isolated from mammary tumors [49].

As in the case of Prep1 hypomorphic mice, functional inactivation of Prep1 (by cytosolic sequestration) caused a reduction in the levels of Pbx2 protein.