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They differ from mice in that much of their neurogenesis happens while still in the womb, so they do not experience infantile amnesia.
We also found that although Flt3L could expand pre-DC and cDC numbers in the BM and blood in the presence of tumors, this expansion was limited compared to tumor-free mice in that pre-DC or cDC1 numbers only reached levels comparable to untreated tumor-free mice (Fig. 9a, b).
When we removed the feedforward inhibition onto PCs and decreased the average strength of GC to PC synapses, a compensatory mechanism that has been observed in the PC-Δγ2 mice11,16, the model reproduced the spiking phenotype of PC-Δγ2 mice in that both the amplitude of modulation and firing frequency were significantly increased after learning (Fig. 4f and Table 4).
In addition to insensitivity to malaise-induced reward devaluation, we found that DBA/2J mice were similar to C57BL/6J mice in that they by and large showed robust PIT, extinction and reinstatement.
Immunological analysis showed that I/St mice differed from less susceptible A/Sn mice in that they exhibited lower antimycobacterial responses [11], [17] and more prominent inflammatory reactions [11], [16], [18].
These results contrast with observations in COX-deficient mice in that COX-1 deficiency led to a greater hyperthermic response and COX-2 deficiency abrogated the development of hypothermia [11].
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Roll your mouse in that box.
A team from Blaser's lab then fed antibiotics to mice in dosages that were comparable to those used to treat children with ear infections.
Wallace points to the widespread creation of animals – mice in particular – that have been genetically altered so they succumb to human conditions such as obesity and cancer.
GDF11 was clearly shown to have rejuvenating effects in heterochronic parabioitic models (where blood is shared between a young mouse and older mouse), and in mice that received GDF11 alone.
However, it is inefficient to generate knock-in mice that carry a reporter gene.
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