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They eliminated aggressive, incurable liver tumours in laboratory mice in four weeks, they report in an advance paper in Nature today.
In order to assess a new strategy for DNA vaccine formulation and delivery, plasmid encoding Plasmodium yoelii MSP-1 C-terminal was formulated with newly designed nanoparticle an anionic ternary complex of polyethylenimine and γ-polyglutamic acid (pVAX-MSP-1/PEI/γ-PGA), and intravenously administered to C57BL/6 mice in four different doses, three times at 3-week interval.
Twelve mice in four metabolic cages constituted an experimental run.
MDSFR is performed on nineteen mice in four tissue types including skin, liver, normal tongue and in an orthotopic oral squamous cell carcinoma.
Yang et al. [ 14] compared microarrays of 169 female and 165 male mice in four tissues (whole brain, liver, skeletal muscle and gonadal adipose), the largest study to date of sex differentially expressed genes.
(B ) Accuracy relative to baseline for four mice in four conditions: optogenetic stimulation triggered at the peak (purple) or trough (teal) of theta, in either the retrieval (left) or encoding (right) segments of the track.
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Kliethermes, C. L. et al. Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation.
CS6-PLG and CS6 were administered intranasally (IN) to BALB/c mice in three vaccinations 4 weeks apart.
In the BLM + PM014 group, mice in three subgroups were treated with PM014 at a dose of 50, 100, or 200 mg/kg.
In successive experiments, they induced sensory deprivation in the mice in three different ways cauterizing rows of whiskers, genetically reducing the transmission of sensory inputs to the barrel cortex, and removing whiskers to see if vascular complexity changed.
In the research reported Thursday, Dr. Tonegawa's team first put mice in one environment and let them get used to it and remember it.
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