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All Gulo−/− mice implanted with B16-F10 and LL/2 cells (10 cells/mouse implanted s.c).
Mice implanted with MTLn3-GFP-ErbB1 cells had significantly more lung metastases than mice implanted with MTLn3-GFP cells (Fig. 2a) also evidence by fluorescence imaging (Fig. 2b).
All mice were killed on day 25 after tumour cell implantation, and lung metastasis score was higher when applied to lungs of mice implanted with SP of D121 tumour cells than in mice implanted with non-SP control cells.
Working with another team led by Wayne Tilley at the University of Adelaide, Carroll's group performed a series of experiments on human breast cancer cells and on mice implanted with human breast tumours.
The two-wave treatment arrested tumor growth in mice implanted with either human colon or human breast tumors, and enabled mice with drug-resistant human uterine tumors to eliminate the tumors altogether.
(B) Weight of tumors from mice implanted with SGC7901 cells.
To investigate, Schwarz and colleagues observed mice implanted with healthy and dead bone implants.
The company is currently testing the compounds on mice implanted with human tumors.
In contrast, no NIS expression was observed in the liver tumor cells of mice implanted with negative control tumor fragments.
Furthermore, the mice implanted with human xenograft tumors do not react immunologically as do the human tumors.
Mice co-transplanted with M2 TAMs and POSTN-silenced GSCs show a shortened survival relative to mice implanted with POSTN-silenced GSCs alone.
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Justyna Jupowicz-Kozak
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