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Immunization with either disulfide or thioether linked vaccine constructs effectively inhibited EG7-OVA tumor growth in mice, however only treatment with the thioether linked vaccine construct resulted in enhanced survival.
Here we show that glomerular gelatinase expression, specifically matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-14, was significantly elevated in both integrin α1-null mice and integrin α1-null Alport mice relative to wild-type mice; however, only MMP-9 was elevated in glomeruli of Alport mice that express integrin α1.
Such pathfinding errors can be seen occasionally in wild-type mice, however only for a few RGC axons.
Thus, based on gray values, we established that the extent of remyelination was higher in all rhGas6-treated mice versus PBS-treated mice; however, only the 4 µg/ml and 40 µg/ml groups were statistically significant.
In Ildr1−/− mice, however, only OHCs and not IHCs undergo progressive degeneration during early postnatal development.
Adoptive transfer of antibodies to citrullinated collagen frequently induced arthritis in naïve mice, however, only when co-administered with antibodies to unmodified collagen [ 118].
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In PECAM-1-knock-out-mice, however, only a slowing of inflammatory cells transmigrating through the basement membrane was observed.
In neurons from Dp71-null mice, however, colocalization only reached 27.9±4.48% and the number of clusters double-stained with VGLUT1 and PSD-95 (Figure 4, A3 and A7) was significantly reduced (11.77±1.39 per 50 µm) compared to WT mice (32.62±2.22) (p<0.0001), which likely reflected a reduced density of functional synaptic junctions.
These mice, however, were only followed for 8 weeks post reconstitution and this may not have allowed sufficient time for the dermatitis to develop.
Telomerase abrogation in cancer-prone mouse models, however, only decreased tumor growth after several mouse generations when telomeres reach a critically short length, and this effect was lost upon p53 mutation.
Overall, a higher concentration of H5-specific antibodies was detected in chicken than in mouse sera; however, only two of the H5tr chicken serum samples and three of the H5 mouse serum samples gave low positive HI results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com