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Zonulin-type mice have two copies of the gene related to a high production of zonulin.
These findings are best explained by the fact that XX mice have two actively transcribed copies of Jarid1c due to escape from X inactivation.
The two BA peaks in serum suggest that mice have two episodes of food ingestion in the dark phase, mimicking the postprandial increase of serum BAs in humans [26].
This difference may be explained by the fact that mice have two Ceacam genes (Ceacam1 and Ceacam2) that are differentially expressed in the kidney [35], [37], while humans have a single CEACAM1 gene.
On the fourth day, mice have two test sessions.
These 'low copy' mice have two copies of the oncogenic rabbit transgene.
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These mice have five distinct human mutations in two genes, the amyloid precursor protein (APP) and Presenilin1 (PS1) engineered into two transgenes driven by a neuron-specific promoter (Thy1), and thus develop severe amyloid deposition by 4 months of age.
Humans and mice have four functional FOXO genes (−1, 3, 4, and 6), while flies (dFOXO) and worms (DAF-16) have one [13].
DD mice have one intact dopamine β-hydroxylase (Dbh) allele, and one Dbh allele with targeted insertion of the Th gene to allow for normal production of norepinephrine [24], [25].
Although humans normally have only one functional CYP2D gene, mice have nine functional Cyp2d genes (Nelson et al. 2004), and there are 12 rodent Cyp2d genes that show evidence of positive selection (Thomas 2007).
The mice had two types of mitochondria that differed by one letter of the genetic code.
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