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Both lines of mice have significant increases in dermal vasculature but only the KC-Tie2-overexpressing mice developed a cutaneous psoriasiform phenotype.
Leptin-deficient mice have significant abnormalities in macronutrient metabolism, which can be corrected by leptin administration.
Although maternal deletion mice have significant impairment in rotarod test, there was no difference for the travel distance and speed in open field test.
Despite this progress, HIS mice have significant limitations with respect to longevity of engraftment, production of myeloid cell populations, and the consistency of immune cell function in experimental replicates within a group[10].
In a previous study, our laboratory showed that B6 mice have significant withdrawal of cardiac parasympathetic tone during acute CB exposure (Tankersley et al. 2007).
These data show that the antibodies contained in sera from ECD/Her2-immunized mice have significant anti-proliferative effects in SK-BR-3 cells.
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Similarly, mice had significant increases in wet-to-dry weight ratio by day 3 following treatment with IT bleomycin (Fig. 4b).
Compared to sham-operated animals, OVXed mice had significant reductions in trabecular bone volume, connectivity density, DBM, and bone biomechanical properties (P < 0.05).
High fat diet fed mice had significant fat deposition in the aortic root at 0.63 ± 0.02 mm2, which was significantly reduced by the supplementation of VSL#3 (0.38 ± 0.04 mm2), T1 (0.32 ± 0.01 mm2) and its combination (0.29 ± 0.12 mm2) (Fig. 1a).
HPLC analysis indicated that LEO-gavaged mice had significant differences in the concentrations of norepinephrine, dopamine, and serotonin in the prefrontal cortex, striatum, and hippocampus, which might, at least in part, account for the antidepressant effect of LEO.
Test mice had significant gene marking 8 12 months post-transplantation with an average of 0.93 vector copies per cell and 41.5% of peripheral blood cells expressing the transgene MGMTP140K, thus confirming persistent vector expression.
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