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From a metabolic and related mechanistic stand-point, NOD and db/db diabetic mice have several fundamental differences [22], [30], [37].
Our GAD67-GFP BAC transgenic mice provide another genetic tool for studying adult neurogenesis, and these mice have several unique features.
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In contrast, an extensive study (with two mouse models: wild-type FVB/N and genetically engineered mice having several copies of human SULT1A1 and SULT1A2 at chromosome 9), Florian et al. [50] yielded opposite findings (i.e., neither HMF nor its metabolite SMF induces ACF and colonic tumors).
The use of AAV-Cre and floxed CNTFRα mice has several advantages.
The generation of KO mice has several limitations in this context: (i) requires the ablation of the multiple gene copies of miRNAs belonging to the same family, often placed at distant genomic loci and (ii) miRNAs genes are frequently encoded in clusters together with other miRNAs from different families or directly overlapping other protein-coding or lncRNA genes.
Within the Bilateria, vertebrates such as the human and mouse have several representatives from each major Sox group.
The Vav2/Vav3-deficient mouse has several characteristics which make it particularly useful as an animal glaucoma model.
The quaking viable (qkv) mouse has several developmental defects that result in rapid tremors in the hind limbs.
As a model organism, the laboratory mouse has several distinct features that are key for this study.
The increased rate of lung metastasis observed in Shb deficient mice may have several explanations.
For obvious reasons, mouse models have several advantages over human studies.
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