Mmp13−/− mice have normal body size.
For example, when Ikkβ is knocked out in hepatocytes, the livers of the knockout mice have normal development, but exhibit elevated levels of reactive oxygen species (ROS).
However, unlike Tfr+/− mice showing an increase in the number of red cells (Levy et al., 1999), Stx-t+/− mice have normal hematological indices as wild-type (Fig. 1G).
Gelsolin homozygous mutant mice have normal embryonic development and longevity.
These mice have normal baseline hematopoiesis, but defective erythropoietic responses to stress [30].
Mbnl1−/− mice have normal spatial learning and memory but show severe alterations in motivated behavior.
Snord116 deletion mice have normal muscle strength but a defect in motor learning.
CXCR2−/− mice have normal numbers of thymic eosinophils and macrophages relative to WT mice at steady state (data not shown).
Finally, both humans with CACNA1F mutations and Cacna1fnob2 mice have normal photopic and scotopic a-wave amplitudes [35], [36], (Figure 5).
Most recently, Le Beau and colleagues observed that Egr1 heterozygous mutant mice have normal resting hematopoiesis, but develop myeloid diseases after treatment with ENU [17].
Ad libitum (ad lib) fed N2KO mice have normal food intake and leptin levels until they become overtly obese after 20 weeks of age [27].
