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Our results suggest that the db/db mice have multiple AD-like brain changes including impaired cognitive functions, increased phospho-tau and Aβ as well as decreased synaptic proteins.
However, these mice have multiple defects, ranging from abnormal spleen morphology to reduced numbers of CD4 and CD8 T cells as well as dendritic cells [29], [30].
Shh-NTKO mice have multiple large pNEBs that scarcely express Hes1 (Fig. 5D,E).
Despite these considerable attributes, mice have multiple limitations for use in the analysis of psychiatric disorders.
At the age of 10 weeks these mice have multiple mammary tumors 0.15 0.17 cm in diameter.
Sumf1 KO mice have multiple abnormalities, including reduced viability, growth retardation, seizures, kyphosis, joint deformaties and lysosomal storage disease involving GAG accumulation.
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Because the asthma-prone mice had multiple mutations in both genes, the researchers couldn't determine whether one, the other, or both cause asthma.
Upon histological analysis, all CK19CreERT; LSL-KrasG12D mice had multiple benign lung tumors consisting primarily of papillary adenomas that became densely packed in the larger lesions (Figure 4A, B) [23] while all single gene controls were histologically normal.
Seen in cross-section, the choroid plexus epithelium of Bbs1 miceR/M390R mice had multiple intact basal bodies.
Untreated mice had multiple mammary carcinomas at six months of age while almost all vaccinated mice were tumor-free at one year of age doubling the life expectancy of these mice.
However, Peters et al. (1997) had previously reported the absence of tumors in nine PPAR-α null mice exPPAR-α null-14,643 at 11 micehs, whexposedach of toe six similarly exposed Wy-14,643 mice hat multiple hepatocellular neoplasms.
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