These mice have lower levels of oxidative stress and apoptosis, both of which have been linked to old age survival in man.
The garlic-fed mice have lower plasma erythropoietin than the controls, however.
Compared with gal3+/+ mice, gal3−/− mice have lower DTH responses and produce higher titers of IgG1.
Ovariectomized mice have lower levels of many antioxidant enzymes in the heart, including glutathione peroxidase, catalase, and superoxide dismutase [21], [22].
We have previously reported that female CXCL14−/− mice have lower body weight than CXCL14+/− mice on a C57BL/6-CBA mixed background [6].
Moreover, we show that LTβR or LTβ deficient mice have lower numbers of ICAM/CD54+ and CD69+ CD8 T cells than wild type or TNF deficient mice upon PbA infection (Figure 4C,D, H, I).
B6 WT mice have lower serum cholesterol (both sexes), and higher sALP (females), as well as greater weight loss (both sexes), and more enlarged livers (both sexes) than do WT 129, and sometimes F1, mice.
Both mdx nu/nu mice and mdx/SCID mouse strains have the same mutation in their dystrophin gene, but are on different genetic backgrounds and are immunocompromised in slightly different ways: SCID mice have lower B cell function than nu/nu mice, although both lack T cells and retain macrophage and NK cell activity.
In addition, in both the knock-out mouse model of Fragile X and peripheral blood lymphocytes from individuals with fragile X, a condition associated with autism, Berry-Kravis et al [45] showed delayed phosphorylation of ERK, partly overlapping our observation that PolyI C mice have lower MEK and pERK.
