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Genome-wide epigenetic profiles in mice have linked Lys14 acetylation to a subset of inactive promoters "poised" for transcriptional activation.
Studies of apolipoprotein E deficient (ApoE /–) mice have linked exposure to concentrated air particles over 4 6 months with increased aortic atherosclerotic plaque (Chen and Nadziejko 2005).
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A surprise discovery in mice has linked a mysterious class of molecules to asthma and may bolster the theory that the respiratory disease is a misplaced reaction to parasites.
Gene amplifications on the sex chromosomes are particularly interesting; recent work in mice has linked the amplification of gene families on both the X and Y chromosomes to an ongoing genomic conflict affecting X gene expression and ultimately sex ratio skewing [ 14].
In experiments with mice, researchers have linked these genes to weight gain and even to the "lost in time" feeling of marijuana use, but they've had a harder time studying them in humans.
Numerous mouse crosses have linked HDL to this region and Apoa2 has been identified as the gene underlying the QTL (Wang et al. 2004).
Human epidemiological studies, as well as transgenic mouse models, have linked genetic variations in IRAK genes to a collection of diverse diseases including cancer.
Various mouse models have linked bioenergetic status of oocytes to abnormal meiotic outcomes, particularly defects in spindle positioning and chromosome scattering (Wang et al., 2009; Luzzo et al., 2012).
Now researchers using a mouse model have linked maternal hypoxia during pregnancy plus the presence of only one functioning copy of the Hes7 gene with up to a 10-times-greater risk of congenital scoliosis in offspring compared with the genetic risk factor alone.
The results are consistent with those of toxicologic studies conducted with mice and rats that also have linked exposure to PFOS and PFOA with low birth weight albeit at doses that resulted in much higher body burdens than those seen in the Baltimore infants.
A PINK1 knockout mouse model has linked PINK1 with a role in dopamine release and striatal plasticity [16], as well as defects in mitochondrial respiration [17].
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