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Obese, leptin-deficient (Lepob) mice have large gallbladder volumes with decreased contraction in vitro and are predisposed to cholesterol crystal formation.
African spiny mice have large eyes and ears and scaly, nearly bald tails that are shorter than or about as long as the body.
PTENpc−/−/Hi-MYC bigenic mice have large prostatic adenocarcinomas at 3 months (Fig. 2), well in advance of either of the well-established single lesion models, which at this stage harbor mPIN exclusively (Fig. 2).
Compared to most other strains, cortical bones in C57BL/6J mice have large diameters but low thickness, and therefore low areal BMD.
This runs counter to the view that mice have large amounts of higher order aberrations and encourages the prospects for resolving cellular structures in the rodent retina even without AO.
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Here, we show that cuffed-arteries in Cav-1 null mice have larger intimal area and intima-media ratio than WT mice.
Nevertheless, liver weights in male mutant mice after cholate diet consumption were still higher in B6, than in 129 or F1, mice (p<0.001, both comparisons); in female mutants after cholate feeding, B6 and F1 mice have larger livers than 129 mice (B6 versus F1: p<0.01; 129 versus F1: p<0.001; Figure 7b).
While brown adipocytes of wild type mice have larger mitochondria in their cytosol with dense and regular cristea aligned along the mitochondrial matrix, mitochondria from Fsp27−/− brown adipocytes were irregular in size and had significantly fewer cristea in its matrix, suggesting their lower activity in BAT (Fig. 4A).
Also, wild-type mice have larger infarcts compared with those deficient in IL-1.
However, all 11β-HSD1 null mice have larger adrenals often with an exaggerated glucocorticoid response to stress [38].
Animal data have suggested a neuroprotective role for gelsolin since gelsolin-null neurons enhance cell death and gelsolin-null mice have larger infarct sizes following ischemia [ 5].
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