So viral immunologist Herbert Virgin of Washington University School of Medicine in St .Louis, Missouri, reasoned that latently infected mice might be more resistant to bacterial infection, because those mice have higher blood levels of IFN-γ.
Ob/ob mice have higher iron absorption as compared to lean mice [22].
We have also found that PD-1−/−Foxp3gfp mice have higher numbers of natural Tregs compared to WT mice.
However, IL-6-deficient mice have higher mortality than wild-type mice after ocular inoculation with HSV [52].
PECAM-1−/− mice have higher levels of HSC progenitors in the blood compared to their littermate controls.
OPN deficient mice have higher TUNEL staining and less papilloma development when treated with carcinogen compared to WT mice [44].
To determine whether Mstn−/− mice have higher glucose uptake than Mstn+/+ mice, we carried out a hyperinsulinemic-euglycemic clamp experiment.
Because mice have higher glucose levels than humans, the transplanted beta cells were exposed to mild hyperglycemia and the abnormal environment of the transplant site.
In this report, we show that MT4-MMP-null mice have higher baseline urine osmolarities and consume less water than wildtype controls.
In support of this, it was recently shown that IRAK−/− mice have higher Treg proportions compared to wild type mice, suggesting that IL-1 signaling could be negatively regulating Treg development or maintenance [36].
We did not conduct immunohistochemistry for CP, but if increased CP is localized in the RGC layer of mutant animals, it would provide evidence that P4 Chrnb2−/− mice have higher rates of RGC death compared to WT animals.
