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Furthermore, selective moderate over-expression of NCS-1 in the dentate gyrus of mice has recently been found to promote rapid acquisition of spatial memory [23].
This finding is particularly important given that a common Adeno-Associated Virus (AAV) insertion site in mice has recently been identified that maps between miR-341 and miR-370 in Meg8 that causes hepatocellular carcinomas, suggesting that perturbed expression of microRNAs may be responsible.
Expression analysis on brains of 5HTT knockout mice has recently been performed[ 25].
Its involvement in promoting colitis via taurine metabolism in mice has recently been established (Devkota et al., 2012).
The defective maturation of NK cells in aged mice has recently been confirmed by other groups (Chiu et al., 2013; Beli et al., 2014).
Interestingly, APOBEC2 deficiency in mice has recently been associated with a shift to a slow-fiber type in muscle, and with diminished body mass and mild myopathy [ 120].
Similar(46)
Such targeted introductions of mutations to generate "knock-in" mutant mice, have recently been used to create models of ocular disease that closely mimic their human counterparts [19] [21].
Genetic approaches in mice have recently implicated hunger and arousal hormones/peptides in mediating FAA [6] [10], furthering the notion that hypothalamic circuitry is critically involved in mediating anticipatory activity (AA).
These included Dmp1 and Phex, two genes required for bone matrix mineralization and phosphate homeostasis (41,42), but also the three genes encoding type IX collagen, which is potentially important, since Col9a1-deficient mice have recently been described to display an osteoporotic phenotype [44].
MiR-151 knockout mice have recently been used to demonstrate miR-151's protection against cisplatin-induced kidney injury [ 7].
Furthermore, LTi-like cells in adult mice have recently been shown to restore splenic architecture after viral infection 35.
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