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A study comparing the gene profile of limbal and corneal basal cells in mice has noted preferential expression of epithelial SC genes such as FGFR1 (Fibroblast Growth Factor Receptor 1) and S100A6 (S100 calcium binding protein A6) in limbus [ 23], however we had noted upregulation of these molecules in the corneal epithelium.
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This rapid recovery after an insult in mice has been noted previously [ 16, 17].
Accordingly, IFN-α production in IBD model mice has been noted in both CD11b+ and CD11c+ dendritic cells in colonic lamina propria [ 60].
Perhaps interesting, we had noted that KO mice manifested breathing difficulties under deep isoflurane anesthesia when we implanted the telemetric devices.
Having noted that Ku86-/ mice are susceptible to dehydration from even a very limited restriction of water, we were led to wonder whether they might be chronically dehydrated enough to raise their blood NaCl sufficiently to contribute to premature cellular senescence and aging.
We (41) have noted higher basal plasma corticosterone levels in FVB/N mice.
This prednisone-induced decrease in body weight and reduction of weight gain in mdx mice has also been noted in previous studies [8], [9].
It is interesting to note, however, that analysis of Apelin and Aplnr mutant mice has in some cases noted discrepancies in what would be expected to be identical phenotypes (Charo et al., 2009; Ishida et al., 2004; Kuba et al., 2007).
Lexicon's Rassf5 KO mice had craniofacial malformations noted by gross observations and CAT scans (skulls had reduced length, a short nasal bone, a short zygomatic bone and a short mandible with a stunted coronoid process).
Age-related CNS findings in Nfkb1 −/− mice have also been noted by others including hearing loss and spiral ganglion cell depletion [ 35], retinal ganglion cell loss [ 36] and short-term spatial memory deficits [ 37].
The lack of conservation in both size and sequence of the central portion of the TACC3 proteins of human and mouse has been previously noted, and accounts for the major difference between these two orthologues [ 2].
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