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Although rat models had been standard models of PH research, in more recent years the availability of genetically engineered mice has made this species attractive for many investigators.
The advent of transgenic immune-deficient mice has made it possible to generate chimeric animals harboring human tissues and cells, including hepatocytes.
The detailed knowledge of the murine genome, the various components of the murine immune system, and the generation of engineered mice has made the murine system the most attractive among all animal models.
However, the severe neurological phenotype of Scn1b null mice has made a detailed analysis of β1 function in vivo quite challenging.
Our work over many years with congenic and transgenic mice has made us aware of pitfalls relating to the purity of genetic backgrounds.
The availability of high-density genotype data for mice has made it possible to quantify the relationship between haplotype structure and differential gene expression.
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Researchers studying mice have made a discovery that is certain to upset anyone who loves the rump end of beef but worries about mad cow disease.
Animal models of malaria, mainly mice, have made a large contribution to our knowledge of host pathogen interactions and immune responses, and to drug and vaccine design.
Phenotypic analyses of Cox1 and cox-2 null mice have made it clear that the role of these genes in a developing organism is much more complicated than was once thought.
Whether or not we agree with how animals have been used as experimental models in laboratory research, particularly for drug discovery and to understand human diseases, we should not deny the contribution that rats and mice have made to scientific and medical advances.
The corporate university will build better mousetrap after better mousetrap, but never fix the hole in the wall where the mice have made their nest.
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