Sentence examples for mice has led from inspiring English sources

Furthermore, the analysis of genetically engineered mice has led to the discovery that desmosomal proteins are also required for normal embryonic development.

The skin phenotype observed in p63−/− mice has led to the formulation of two hypotheses concerning the biological role of p63 in epidermal development [16], [17].

The availability of various experimental models for PD, based on αS overexpression (mutant or wild form) in flies or mice, has led research scientists to study the effects of various compounds on the progression of PD symptoms [ 3].

Comparison of CellsControlCMControl to CellsRas-G12V+TNFαCMControl (groups 1 vs. 3, Figure  6B) has shown that expression of RasG12V in the cells (stimulated in vitro by TNFα prior to their injection to mice), has led to increased tumor growth.

Mono-allelic deletion of BECN1 in C67/B6 mice has led to the formation of spontaneous lung and liver cancers as well as lymphoma but only mammary hyperplasia (Qu et al., 2003).

The observed heterogeneity of popliteal LN draining capacity, and its recognized pathophysiologic relevance during the spontaneous course of the disease in TNF transgenic mice, has led to further studies aimed at characterizing the cellular regulatory mechanisms of these processes.

Genetically engineered mice have led to the development of new insights into the etiology and pathogenesis of thrombophilia-associated fetal loss.

These studies, which have been facilitated by the development of selective pharmacological tools and genetically engineered mice, have led to recognize that the endocannabinoid system plays an important role in the regulation of emotional states.

These observations in mice have led our group to develop a common cause hypothesis that asserts that misexpression of PTP1B, and potentially of other genes causing defects in breast development, may not only cause difficulties in breastfeeding but could also lead to increased risk for breast tumour formation and cancer progression.

Long term treatment with antipsychotics in mice have led to the development of pituitary adenomas and adenocarcinomas [ 85].

Studies in sarcolipin knockout mice have led to the suggestion that skeletal muscle sarcolipin plays a role in thermogenesis.