The business of producing GM mice has increased exponentially over the last 20 years, and yet the rate of new drugs coming on to the market has been steadily decreasing.
In recent years, the use of loxP-containing transgenes in transgenic mice has increased but the possibility of unintended effects of this approach has not been taken into consideration [5], [7], [8], [9], [10], [11], [12], [13], [14], [37], [38], [39], [40], [41].
The characterization of sortilin deficient mice has increased the knowledge of its functions at peripheral and central level.
It is worthy to note that the mean life span of tumor-free mice has increased by 20.7% in 'the youngest age started' group, by +7.1% in 'middle-age started' group and was reduced by 12.8% in the 'old age started' group.
In the past, most studies on the genetics of behavior in mammals have focused on rodents, where the existence of inbred lines, for instance in mice, has increased the power to detect quantitative trait loci (QTL) [ 19] and to identify candidates genes related to behavior [ 20– 20].
On the other hand, our data also showed that GHS-R ablation increases NE-induced O2 consumption, indicative that BAT of Ghsr −/− mice has increased sensitivity to NE stimulation; this suggests that GHS-R ablation may directly affect the thermogenic response of BAT.
Collagen X KO mice had increased levels of IgM, consistent with increased numbers of B lymphocytes (Figs.
Mice with ablation of Phex gene (Hyp mice) have increased FGF23 expression and hypophosphatemia.
The db/db mice had increased Aβ levels.
In line with this, tMCAo mice had increased grid crossings compared to either pMCAo or TBI.
Bleomycin treated mice had increased BAL protein concentration, an indicator of lung vascular permeability.
