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The BAT of these TIF2 knockout mice has enhanced adaptive thermogenic capacity, whereas their WAT is smaller, accumulates less fat and has decreased expression of genes related to fatty acid uptake and trapping.
Although not directly examined, it is plausible that the WAT in TIF2 knockout mice has enhanced potential to browning, given the changes in WAT morphology and the improved metabolic profile of these mice.
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We conclude that Tregs from Krt76−/− mice have enhanced suppressive function and Tresp are less proliferative compared with cells from control mice.
In addition to being more abundant, Tregs from Krt76−/− mice had enhanced suppressive function, which correlated with higher levels of CD39 and CD73 expression (Fig. 4).
In the context of myeloid function, Min et al. (Min et al., 2008) found that EGR1−/− mice have enhanced mobilization of HSCs into the bloodstream.
Furthermore, HPLC analyses revealed that Cnr1/Gad1 mice have enhanced serotonin levels, but not dopamine levels in response to amphetamine.
We demonstrate that NOS1-deficient mice have suppressed inotropic response, whereas NOS3-deficient mice have enhanced contractility, owing to corresponding changes in SR Ca2+ release.
Compared to wild type mice, in vitro derived moDCs from miR-21 deficient mice had enhanced production of IL-12, but not other cytokines (including TNF-α, IL-6, and IL-23) upon stimulation by LPS (Lu et al., 2011).
Thus, our data show that Ghsr-/ mice, but not Ghrl-/ mice, have enhanced mitochondrial activity.
Furthermore, these mice have enhanced retention of cardiac performance with age [21].
Despite large trophic burdens, many of the treated mice had enhanced survival as compared to untreated mice (Figure 2).
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