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Scientific research incorporating the use of mice has advanced rapidly in the last three decades.
Whether ethically right or not, our knowledge of human disease has progressed considerably as our understanding of how we can genetically induce disease in mice has advanced.
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Nevertheless, recent studies on animal models for hereditary photoreceptor degenerations, such as the rd1 mouse, have advanced the knowledge on the pathological processes.
Progress in multiple fields of human and mouse model research has advanced our knowledge of what leads to cognitive decline in AD (for full review [ 5]).
Driehaus' pick has advanced 18%.
Thus, while exenatide can normalize whole-body insulin sensitivity and myocardial glucose uptake in mice that have advanced dilated cardiomyopathy, cardiac contractile function and survival are improved but not to perfect health.
Although engineered mouse strains have advanced cancer immunotherapy, basic shortcomings remain.
Here, we will review how mouse models have advanced our understanding of severe asthma pathogenesis.
Studies with mouse embryos have advanced our understanding of how a pluripotent cell population is established during pre-implantation development [ 1- 4].
Recent insights based on mouse models have advanced our understanding of the molecular mechanisms controlling the function of myogenic progenitors significantly.
Combination therapy with CTLA4 Ig and cyclophosphamide improved proteinuria and prolonged survival when it was given to mice that already had advanced renal disease [ 17].
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