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Because the asthma-prone mice had multiple mutations in both genes, the researchers couldn't determine whether one, the other, or both cause asthma.
Upon histological analysis, all CK19CreERT; LSL-KrasG12D mice had multiple benign lung tumors consisting primarily of papillary adenomas that became densely packed in the larger lesions (Figure 4A, B) [23] while all single gene controls were histologically normal.
Seen in cross-section, the choroid plexus epithelium of Bbs1 miceR/M390R mice had multiple intact basal bodies.
Untreated mice had multiple mammary carcinomas at six months of age while almost all vaccinated mice were tumor-free at one year of age doubling the life expectancy of these mice.
However, Peters et al. (1997) had previously reported the absence of tumors in nine PPAR-α null mice exPPAR-α null-14,643 at 11 micehs, whexposedach of toe six similarly exposed Wy-14,643 mice hat multiple hepatocellular neoplasms.
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Sanford, L. P. et al. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes.
Our results suggest that the db/db mice have multiple AD-like brain changes including impaired cognitive functions, increased phospho-tau and Aβ as well as decreased synaptic proteins.
The ob/ob mice have multiple endocrine abnormalities, including elevated pituitary and circulating beta-endorphin levels; and a relationship between hyperglycemia and altered opioid function has been suspected.
However, these mice have multiple defects, ranging from abnormal spleen morphology to reduced numbers of CD4 and CD8 T cells as well as dendritic cells [29], [30].
Shh-NTKO mice have multiple large pNEBs that scarcely express Hes1 (Fig. 5D,E).
Despite these considerable attributes, mice have multiple limitations for use in the analysis of psychiatric disorders.
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