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However, during the course of a week following the first DT injection, PLR in the Opn4Cre/+ R26iDTR/+ mice gradually lost sensitivity (Figures 4A and 4B).
Untreated Npc1−/− mice began a precipitous weight loss beginning at 6 weeks of age, while combination-treated Npc1−/− mice gradually lost weight starting at 14 weeks (Fig. 1A).
While WT mice gradually lost weight, the Snord116del mice were better at maintaining their weight, with females showing significant and males showing a trend of improved weight stability (Fig. 6F).
The LVSCE/AMVAD immunized mice gradually lost weight for about 12 days post-challenge, and after a stabilization period of about 4 more days, the surviving mice began to regain the lost weight, achieving a gain similar to the LVSCE/CT group.
The 129S2 mice gradually lost weight and most of them died within 40 days postinfection (p.i ., whereas Ifnar1−/− animals survived acute and chronic TB (Fig. 1A; Supporting Information Fig. 1C).
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In addition, UCHL1−/− mice gradually lose their ability to hold on to an inverted wire grid (WT, 60 s, n = 4; UCHL1−/−, 27 ± 5 s, n = 6; P < 0.05; Fig. 1 H).
In an independent mouse model of SCC, we also found that miR-203 expression was gradually lost in a Kras G12D /Smad4 cKO model where skin tumors progressed to invasive SCC through serial passages of tumors (White et al., 2013).
Finally, ANRIL apparently gradually lost exons during rodent evolution, containing numerous exons in guinea pig but none in mouse and rat.
Campanelli said fans gradually lost control.
White abolitionists gradually lost their taste for mahogany.
As a result, they gradually lost their autonomous status.
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