Mice deficient in myostatin and wild-type mice given a myostatin inhibitor both exhibit a profound hypertrophic muscle phenotype (Lee et al., 2005; McPherron and Lee, 1997).
The mice given a transplant had improved glucose metabolism, increased tolerance to cold temperatures and lost body fat.
Of course, in contrast to Ms. Guiliano and Mr. Safer, who were talking about people drinking a glass or two a day, the latest research relies on data concerning mice given a drug at dosages equivalent to drinking hundreds of glasses of wine.
The idea that eating less could slow the ageing process was sparked in the 1930s when researchers at Cornell University found that rats and mice given a restricted diet could live 40% longer, and the concept has since been confirmed by studies on fruit flies and roundworms.
And sick mice given a steady dose of carboxyfullerenes developed the symptoms of ALS later and lived longer.Whether people will ever benefit from a brainful of fullerenes is another question.
As Dr Matzuk and colleagues report in Cell, male mice given a relatively mild doses of JQ1 for six weeks showed an 89% drop in their sperm count, and the sperm they did produce were terrible swimmers.
Mice given a compound that blocks the action of hypocretin, for example, woke up more slowly upon activation of the neurons than did mice given a placebo.
By contrast, the severity of anemia is reduced in NZB mice given a soluble analog of the peptide [9], showing that this disease is susceptible to peptide therapy.
Hemizygous mice given a lethal dose of hCD19 transgene-expressing lymphoma cells and treated with CAR T cells had undetectable tumor levels.
The UPR marker ATF4 is specifically upregulated in GCs and COCs (cumulus-oocyte complex)isolated from pre-ovulatory follicles of mice given a high-fat diet (GRP78 is also upregulated in COCs).
Then the drugged mice's endurance shot through the roof: They ran about 70% farther than trained mice given a placebo, and their running times were similarly increased, Evans's group reports online today in Cell.
