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(Objective) The subventricular zone in mice generates a lot of neuroblasts even during adulthood.

Ablation of the ST14 gene in mice generates a phenotype with compromised epithelial barrier function and fatal outcome [ 18, 19].

Primary isolation of bovine spongiform encephalopathy (BSE) in RIII mice generates a lesion profile believed to be reproducible and distinct from that produced by classical scrapie.

The best explanation for this response is that immunization with AQP4-loop C peptide in AQP4 null mice generates a T cell response that is different from immunization of the same loop in wildtype mice [ 16].

Regenerative medicine has also recently come into play in the context of female reproductive biology based on results showing that bone marrow (BM) transplantation (BMT) into chemotherapy-conditioned female mice generates a small number of donor-derived oocytes contained within immature follicles [ 11, 16] but does not yield mature (fertilization competent) donor-derived eggs [ 16, 17].

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B6D2F1 mice generated a greater humoral and Th1 immune response versus C57BL/6 mice.

We observed that BALB/c mice generated a robust dose-dependent increase in IL-4 production, while in C57BL/6 mice the response was lower (Fig. 3a, note log scales).

Knockout of the VGF gene in mice generated a lean, hypermetabolic, hyperactive phenotype, demonstrating that VGF may regulate energy balance [19].

The 12,365 gene list generated in this way was further filtered for genes differentially expressed only between oAC-treated and untreated PbA-infected mice, generating a list of 99 genes.

As reported in Fig. 4, all groups of mice generated a comparable TRP-2-specific CTL response, therefore confirming that tolerance in TRAMP and TRAMPJα18−/− mice is restricted to the PC-associated antigen.

While WT mice generate a protective Th2-biased immune response to a high dose of Trichuris, a low dose (30 eggs) of Trichuris induces a Th1 cell response resulting in chronic infection [21].

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