Arginine butyrate-treated mice gene expression profiling experiments revealed that several genes that control cell proliferation, growth and differentiation are differentially expressed consistent with its histone deacetylase inhibitory activity when compared to control (saline-treated) mdx mice.
To detect the primary transcriptional changes associated with the development of DPN in Ins2Akita/+ mice, gene expression profiling of the DRG and of the sciatic nerve endoneurium were carried out.
Utilizing the hippocampi of control versus stressed anhedonic and non-anhedonic mice, gene expression profiling has been performed using Illumina technology (IntegraGen, Evry, France) and the Ingenuity Pathway Analysis program (Ingenuity Systems, Redwood city, CA, USA).
To gain insights into why the absence of FATP4 in utero causes the severe skin defects in mice, gene expression profiling was used to search for significant changes at embryonic day 15.5.
Csnk1a1 and Csnk2a1, which were over-represented in QSi5 mice gene expression profiles, are positive mediators of the pathway, while a lower level of expression was seen for Ppp2r1a, which has a central role in the β-catenin degradation complex.
To investigate the mechanisms underlying Myc-induced B-cell neoplasia (particularly PCTs) in BALB/c mice, gene expression profiles for four groups of BCLs and for PCTs from six different induction protocols (Table 1) were generated.
A major focus of our work is to understand how transplanted neural stem cells modulate this brain plasticity, and other repair pathways related to angiogenesis and inflammation, using genetic mouse models, gene profiling, and gene transfer techniques.
We use genetic mouse models, gene profiling and gene transfer techniques to study how they modulate brain plasticity, as well as other repair pathways related to angiogenesis and inflammation.
Mouse gene expression profiling data during SC development were collected from an independent study [ 16].
For light-regulated gene profiling, mice were maintained in DD then exposed to 1 hr light at CT30, 40, or 46, while control (no light pulse) mice were left in dark.
